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Modulation of developmental immune programming and protection against cardiovascular disease, diabetes, infectious diseases, and cancer
US8961982B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8961982-B2 |
| Application number | US-13905308-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 13, 2008 |
| Priority date | Dec 16, 2005 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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Maternal adaptive immunity conveys temporary humoral immune protection to neonates. The disclosure demonstrates the influence of the in utero environment on adult atherosclerosis and provides evidence for persistent effects of maternal immunization on adult immune responses. The disclosure provides methods and compositions useful for immunization and more particularly for actively modulating the fetal programming of the immune system for the purpose of preventing or treating immune-modulated diseases. The disclosure also provides interventions to protect offspring and immunized subjects against insulin resistance.
First claim
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What is claimed is: 1. A method of immunization, comprising administering an antigen containing epitopes formed by oxidation or glycation of a phospholipid to a pregnant subject or soon to be pregnant subject, wherein the immune response in the pregnant subject or soon to be pregnant subject induces non-passive immune programming in the resulting offspring to the antigen, so that the resulting offspring produces IgG and IgM, or IgM antibodies to the antigen, wherein the antigen is…
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- A61K39/0012Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US8961982B2 cover?
- Maternal adaptive immunity conveys temporary humoral immune protection to neonates. The disclosure demonstrates the influence of the in utero environment on adult atherosclerosis and provides evidence for persistent effects of maternal immunization on adult immune responses. The disclosure provides methods and compositions useful for immunization and more particularly for actively modulating th…
- Who is the assignee on this patent?
- Palinski Wulf, Yamashita Tomoya, Univ California
- What technology area does this patent fall under?
- Primary CPC classification A61K39/0012. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).