Compositions and methods that inhibit il-23 signaling
US-2024425579-A1 · Dec 26, 2024 · US
US8961980B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8961980-B2 |
| Application number | US-201213710828-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 11, 2012 |
| Priority date | Mar 14, 2007 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
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The invention claimed is: 1. An isolated antibody having the ability of binding to an epitope located within the extracellular domain of the protein comprising the amino acid sequence of SEQ ID NO: 2 and mediating inhibition of proliferation of cells, wherein said cells express a protein comprising the amino acid sequence of SEQ ID NO: 2 and/or are characterized by association of a protein comprising the amino acid sequence of SEQ ID NO: 2 with their cell surface.…
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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