Berberis composition for cognitive health
US-2024424045-A1 · Dec 26, 2024 · US
US8961972B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8961972-B2 |
| Application number | US-201314039113-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 27, 2013 |
| Priority date | Aug 12, 2010 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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The present invention provides anti-N3pGlu Aβ antibodies or antigen-binding fragment thereof. In addition, the present invention provides the use of the anti-N3pGlu Aβ antibodies or antigen-binding fragment thereof for the treatment of Alzheimer's disease.
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We claim: 1. A human engineered anti-N3pGlu Aβ antibody comprising a Light chain Variable Region (LCVR) and a Heavy chain Variable Region (HCVR) wherein LCDR1 is KSX1X2SLLYSRX3KTYLN (SEQ ID NO: 51), LCDR2 is AVSKLX4S (SEQ ID NO: 52), LCDR3 is VQGTHYPFT (SEQ ID NO: 5) and HCDR1 is GYX5FTX6YYIN (SEQ ID NO: 53), HCDR2 is WINPGSGNTKYNEKFKG (SEQ ID NO: 8), and HCDR3 is EGX7TVY (SEQ ID NO: 54), wherein X1 is S or T; X2 is Q or R, X3 is G or S, X4 is D or G, X5 is D or T, X6 is R or D, an…
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