Anti-N3pGlu amyloid beta peptide antibodies and uses thereof

US8961972B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8961972-B2
Application numberUS-201314039113-A
CountryUS
Kind codeB2
Filing dateSep 27, 2013
Priority dateAug 12, 2010
Publication dateFeb 24, 2015
Grant dateFeb 24, 2015

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Abstract

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The present invention provides anti-N3pGlu Aβ antibodies or antigen-binding fragment thereof. In addition, the present invention provides the use of the anti-N3pGlu Aβ antibodies or antigen-binding fragment thereof for the treatment of Alzheimer's disease.

First claim

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We claim: 1. A human engineered anti-N3pGlu Aβ antibody comprising a Light chain Variable Region (LCVR) and a Heavy chain Variable Region (HCVR) wherein LCDR1 is KSX1X2SLLYSRX3KTYLN (SEQ ID NO: 51), LCDR2 is AVSKLX4S (SEQ ID NO: 52), LCDR3 is VQGTHYPFT (SEQ ID NO: 5) and HCDR1 is GYX5FTX6YYIN (SEQ ID NO: 53), HCDR2 is WINPGSGNTKYNEKFKG (SEQ ID NO: 8), and HCDR3 is EGX7TVY (SEQ ID NO: 54), wherein X1 is S or T; X2 is Q or R, X3 is G or S, X4 is D or G, X5 is D or T, X6 is R or D, an…

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What does patent US8961972B2 cover?
The present invention provides anti-N3pGlu Aβ antibodies or antigen-binding fragment thereof. In addition, the present invention provides the use of the anti-N3pGlu Aβ antibodies or antigen-binding fragment thereof for the treatment of Alzheimer's disease.
Who is the assignee on this patent?
Lilly Co Eli
What technology area does this patent fall under?
Primary CPC classification A61P25/00. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).