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US-2016136327-A1 · May 19, 2016 · US
High-throughput, whole-animal screening system
US8961877B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8961877-B2 |
| Application number | US-67088208-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 11, 2008 |
| Priority date | Aug 9, 2007 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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Distinctive components that enable high-throughput, whole-animal screening are described. These components can be used individually or in various combinations. A staging chip strains off the excess fluid that the input animals are immersed in, increasing their density (number of animals in a given volume) and rapidly bringing them close to other fluidic components. A microfluidic sorter is adapted to isolate and immobilize a single, physiologically active animal in a selected geometry. A multiplexed micro-chamber chip receives single animals and the microchamber chip includes individually addressable screening chambers for imaging, incubation and exposure of individual animals to selected chemical compounds. An imaging structure generates sub-cellular, high-resolution images of the physiologically active animals. A well-plate interface chip is used to deliver elements from a compound library to a single output of the chip.
First claim
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What is claimed is: 1. High throughput, whole-animal screening system comprising: microfluidic staging device to concentrate animals; microfluidic sorter adapted to isolate and/or immobilize a single animal using a mechanical means including suction; a multiplexed micro-chamber chip for receiving an animal from the sorter, the chip including individually addressable screening chambers, each screening chamber including structure for immobilizing animals against a plurality of s…
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Human Necessities · mapped topic
Operations & Transport · mapped topic
Operations & Transport · mapped topic
Operations & Transport · mapped topic
Operations & Transport · mapped topic
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- What does patent US8961877B2 cover?
- Distinctive components that enable high-throughput, whole-animal screening are described. These components can be used individually or in various combinations. A staging chip strains off the excess fluid that the input animals are immersed in, increasing their density (number of animals in a given volume) and rapidly bringing them close to other fluidic components. A microfluidic sorter is adap…
- Who is the assignee on this patent?
- Yanik Mehmet F, Rohde Christopher, Angel Matthew M, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5082. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).