Antibodies to human programmed death receptor PD-1

Patent metadata

Field	Value
Publication number	US-8952136-B2
Application number	US-201213719756-A
Country	US
Kind code	B2
Filing date	Dec 19, 2012
Priority date	Jun 18, 2007
Publication date	Feb 10, 2015
Grant date	Feb 10, 2015

Abstract

Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell through the PD-1 pathway is also disclosed.

First claim

We claim:

1. An isolated antibody or antibody fragment which binds to human programmed death receptor-1 (PD-1), comprising
a. light chain CDRs of SEQ ID NOs: 9, 10 and 11; and
b. heavy chain CDRs of SEQ ID NOs: 12, 13 and 14;
wherein said antibody or antibody fragment blocks binding of human PD-L1 and human PD-L2 to human PD-1.

2. The antibody or antibody fragment of claim 1 , comprising:
a. a heavy chain variable region comprising SEQ ID NO: 5; and
b…

Assignees

• Merck Sharp & Dohme

Inventors

• Carven Gregory John
• Van Eenenneem Hans
• Dulos Gradus Johannes

Classifications

• A61P31/00

  Human Necessities · mapped topic

• A61P35/00

  Human Necessities · mapped topic

• A61P37/04

  Human Necessities · mapped topic

• G01N33/57585

  Physics · mapped topic

• C07K2317/92

  Chemistry & Metallurgy · mapped topic