Novel pyrazol derivatives
US-2015376192-A1 · Dec 31, 2015 · US
US8952016B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8952016-B2 |
| Application number | US-87404910-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 1, 2010 |
| Priority date | Feb 27, 2009 |
| Publication date | Feb 10, 2015 |
| Grant date | Feb 10, 2015 |
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This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. The compound of the invention are represented by one of the following structural formulas: The variables for these structural formulas are described herein. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.
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What is claimed is: 1. A compound of Formula C: or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from —CH 3 and —CD 3 ; R 5 is hydrogen or deuterium; and Y is fluorine, wherein the compound has at least 50.1% deuterium incorporation at each position designated as deuterium. 2. The compound of claim 1 , wherein R 1 is —CH 3…
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