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Inhibition of delta-6 desaturase for the treatment of cardiometabolic disease
US8952012B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8952012-B2 |
| Application number | US-201313902435-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 24, 2013 |
| Priority date | May 24, 2012 |
| Publication date | Feb 10, 2015 |
| Grant date | Feb 10, 2015 |
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Abstract
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Systems and methods for screening whether a candidate compound inhibits delta-6 desaturase activity are disclosed. Also disclosed is a transgenic mammal which overexpresses a gene encoding delta-6 desaturase and an animal model of a cardiometabolic disorder or disease that includes the transgenic mammal. A method of treating a cardiometabolic disorder or disease is also disclosed.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for identifying a test compound as a candidate compound for the treatment of a cardiometabolic disease or disorder in a mammal by inhibition of delta-6 desaturase, the method comprising a) contacting a mammalian delta-6 desaturase (D6D) with the test compound; b) determining a change in the level of at least one index of D6D activity in the presence of the test compound, wherein the at least one index of D6D activity is selected from the arachidonic…
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- C12Q1/26Primary
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Human Necessities · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US8952012B2 cover?
- Systems and methods for screening whether a candidate compound inhibits delta-6 desaturase activity are disclosed. Also disclosed is a transgenic mammal which overexpresses a gene encoding delta-6 desaturase and an animal model of a cardiometabolic disorder or disease that includes the transgenic mammal. A method of treating a cardiometabolic disorder or disease is also disclosed.
- Who is the assignee on this patent?
- Univ Colorado State Res Found
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/26. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 10 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).