CXCR3 receptor antagonists

Patent metadata

Field	Value
Publication number	US-8952004-B2
Application number	US-201113520234-A
Country	US
Kind code	B2
Filing date	Jan 5, 2011
Priority date	Jan 7, 2010
Publication date	Feb 10, 2015
Grant date	Feb 10, 2015

Abstract

The present invention relates to compounds of formula (I):

and pharmaceutically acceptable salts thereof, wherein R 1 to R 3 , A, B, X, and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

First claim

What is claimed is:

1. A compound of formula (I):

wherein:
A is —CH—;
B is N;
X is —CH 2 —, —CH 2 C(O)—, or —CH 2 CH 2 —;
R 1 is in the D- or E-position and is selected from H, —CN, halogen, —CF 3 , —OCF 3 , C 1-3 alkyl, C 1-3 alkoxy, —CH 2 OH, —S(O) 2 CH 3 , —S(O) 2 NH 2 , amino, mono- or dimethylamino, —NHC(O)C 1-3 alkyl, —NO 2 , —C(O)…

Assignees

• Ginn John David
• Sorcek Ronald John
• Turner Michael Robert
• Wu Di
• Wu Frank
• Boehringer Ingelheim Int

Inventors

• Ginn John David
• Sorcek Ronald John
• Turner Michael Robert
• Wu Di
• Wu Frank

Classifications

• A61P9/10

  Human Necessities · mapped topic

• A61P29/00

  Human Necessities · mapped topic

• A61P25/00

  Human Necessities · mapped topic

• C07D409/14

  Chemistry & Metallurgy · mapped topic

• C07D213/74

  Chemistry & Metallurgy · mapped topic