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Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
US8951981B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8951981-B2 |
| Application number | US-201013377884-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 16, 2010 |
| Priority date | Jun 16, 2009 |
| Publication date | Feb 10, 2015 |
| Grant date | Feb 10, 2015 |
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Abstract
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The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Paraoxonase 1(PON1), in particular, by targeting natural antisense polynucleotides of Paraoxonase 1(PON1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PON1.
First claim
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What is claimed is: 1. A method of upregulating a function of and/or the expression of a Paraoxonase 1 (PON1) polynucleotide having SEQ ID NO: 1 in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one single stranded antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide has at least 80% sequence identity to a reverse complement of a polynucleotide comprising 12 to 30 nucleotides wit…
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- What does patent US8951981B2 cover?
- The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Paraoxonase 1(PON1), in particular, by targeting natural antisense polynucleotides of Paraoxonase 1(PON1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PON1.
- Who is the assignee on this patent?
- Collard Joseph, Khorkova Sherman Olga, Curna Inc
- What technology area does this patent fall under?
- Primary CPC classification C12N15/1137. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 10 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).