Optical coherence tomography systems and methods

Patent metadata

Field	Value
Publication number	US-8948846-B2
Application number	US-67837708-A
Country	US
Kind code	B2
Filing date	Sep 18, 2008
Priority date	Sep 19, 2007
Publication date	Feb 3, 2015
Grant date	Feb 3, 2015

Abstract

In general, in one aspect, the invention features a method that includes using an optical coherence tomography system to acquire a plurality of frames of a sample where each frame includes optical information about the composition of the sample through a section of the sample. The method further includes averaging over two or more of the frames to provide an image of the section of the sample where successive frames of the two or more frames are acquired with a time lapse of 0.05-0.7 seconds. Embodiments of the method may have unique advantages for endoscopic subcellular imaging. For example, they can enable subcellular imaging with low-NA optics (e.g., NA=0.25 or less) while providing morphological imaging of the underlying tissue up to 0.6 mm without focal tracking.

First claim

What is claimed is:

1. A method, comprising:
obtaining a tissue sample exhibiting intracellular motion;
using an optical coherence tomography system to acquire a plurality of frames of the tissue sample, each frame comprising optical information about the composition of the sample through a section of the sample acquired over an acquisition interval t; and
selecting a time lapse interval for averaging over at least two of the frames, such that the time lapse τ between the at l…

Assignees

• Pan Yingtian
• Univ New York State Res Found

Inventors

• Pan Yingtian

Classifications

• G02B3/0087

  Physics · mapped topic

• A61B5/6852 Primary

  Human Necessities · mapped topic

• G01N21/4795

  Physics · mapped topic

• G02B13/22

  Physics · mapped topic

• A61B5/0066

  Human Necessities · mapped topic