hnRNP A1 knockout animal model and use thereof
US8946503B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8946503-B2 |
| Application number | US-201314092678-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 27, 2013 |
| Priority date | Sep 14, 2011 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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A nucleic acid construct comprising a genetic engineered heterogeneous nuclear ribonucleoprotein (hnRNP) A1 gene is provided. A transgenic mouse in which the expression of hnRNP A1 gene has been disrupted is also provided. The mouse is useful for studying the role of hnRNP A1 gene in normal and disease states of a developmental disorder and muscular diseases. Therefore, a method of screening a compound for potential use in prevention and/or treatment of developmental disorder and muscular diseases is further provided.
First claim
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What is claimed is: 1. A transgenic knockout mouse the whose genome is manipulated to comprise a homozygous disruption of hnRNP A1 gene, wherein the mouse exhibits tongue atrophy as compared to a wild-type mouse in which the hnRNP A1 gene is not disrupted, wherein said homozygous disruption of hnRNP A1 gene comprising deletion of exons 2-8 of the hnRNP A1 gene, wherein the mouse exhibits no expression of hnRNP A1 gene, wherein the tongue atrophy comprises degenerated skeletal muscl…
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Physics · mapped topic
Chemistry & Metallurgy · mapped topic
- A61K67/0276Primary
Human Necessities · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US8946503B2 cover?
- A nucleic acid construct comprising a genetic engineered heterogeneous nuclear ribonucleoprotein (hnRNP) A1 gene is provided. A transgenic mouse in which the expression of hnRNP A1 gene has been disrupted is also provided. The mouse is useful for studying the role of hnRNP A1 gene in normal and disease states of a developmental disorder and muscular diseases. Therefore, a method of screening a …
- Who is the assignee on this patent?
- Univ Kaohsiung Medical
- What technology area does this patent fall under?
- Primary CPC classification A61K67/0276. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We do not list related publications for this record yet—either no in-corpus citations or no shared primary CPC matches in our current data slice.