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Process for the preparation of sufentanil base and related compounds
US8946433B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8946433-B2 |
| Application number | US-201113233227-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 15, 2011 |
| Priority date | Sep 17, 2010 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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- Title
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Abstract
Official abstract text for this publication.
The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.
First claim
Opening claim text (preview).
What is claimed is: 1. A process for preparing a compound of Formula (3), the process comprising: (i) contacting a substituted 4-hydroxymethyl-4-aminopiperidine of Formula (2) with a dispersion comprising between about 50 and about 70% by weight (based on the…
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- C07D409/06Primary
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8946433B2 cover?
- The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% …
- Who is the assignee on this patent?
- Orr Brian, Haar Jr Joseph P, Klemm George H, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07D409/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).