Models for Targeted Sequencing
US-2024321389-A1 · Sep 26, 2024 · US
Multi-targeting short interfering RNAs
US8946401B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8946401-B2 |
| Application number | US-201113287493-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 2, 2011 |
| Priority date | Jan 29, 2007 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.
First claim
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What is claimed is: 1. A multi-targeting RNA molecule that targets two or more different desired target sequences, wherein the RNA molecule comprises a first strand having a 5′ terminus and a 3′ terminus and a second strand having a 5′ terminus and a 3′ terminus, wherein the first strand is perfectly complementary to a desired mRNA target sequence, wherein the second strand contains two or more seed matches optimally spaced in a desired 3′ UTR containing target gene, wherein the fi…
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Frequently asked questions
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- What does patent US8946401B2 cover?
- The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting…
- Who is the assignee on this patent?
- Rossi John J, Snove Jr Ola, Ehsani Ali, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification G16B20/50. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).