Selective sigma-1 receptor ligands

Patent metadata

Field	Value
Publication number	US-8946302-B2
Application number	US-201213707418-A
Country	US
Kind code	B2
Filing date	Dec 6, 2012
Priority date	Nov 18, 2008
Publication date	Feb 3, 2015
Grant date	Feb 3, 2015

Abstract

The invention provides compounds of the formulas described herein and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS.

First claim

What is claimed is:

1. A compound of formula XI:

wherein
R 1 is substituted phenyl, or substituted benzyl; and
when R 1 is phenyl, the phenyl of R 1 is substituted with one to five halo, amino, azido, alkyl, or trifluoromethyl groups, or a combination thereof;
when R 1 is benzyl, the benzyl of R 1 is substituted with:
one to five amino, azido, or alkyl groups,…

Assignees

• Wisconsin Alumni Res Found

Inventors

• Ruoho Arnold E
• Hajipour Abdol R
• Chu Uyen B
• Fontanilla Dominique A

Classifications

• C07C211/27

  Chemistry & Metallurgy · mapped topic

• C07C247/16 Primary

  Chemistry & Metallurgy · mapped topic

• C07C211/29

  Chemistry & Metallurgy · mapped topic

• A61P35/00

  Human Necessities · mapped topic

• C07C211/49

  Chemistry & Metallurgy · mapped topic