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Substituted triazole and imidazole derivatives as gamma secretase modulators
US8946266B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8946266-B2 |
| Application number | US-201013382659-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 13, 2010 |
| Priority date | Jul 15, 2009 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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- Title
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Abstract
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The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound of formula (I) or a stereoisomeric form thereof, wherein R 1 is C 1-4 alkyl; R 2 is hydrogen; X is CH; A 1 is CR 3a ; wherein R 3a is C 1-4 alkyloxy optionally substituted with one or more halo substituents; A 2 is N; A 3 and A 4 are each CH; Het 1 is formula (a…
Assignees
- Wu Tongfei
- Gijsen Henricus Jacobus Maria
- Rombouts Frederik Jan Rita
- Bischoff François Paul
- Berthelot Didier Jean-Claude
- Oehlrich Daniel
- De Cleyn Michel Anna Jozef
- Pieters Serge Maria Aloysius
- Minne Garrett Berlond
- Velter′ Adriana Ingrid
- Van Brandt Sven Franciscus Anna
- Surkyn Michel
- Janssen Pharmaceuticals Inc
- Cellzome Ltd
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8946266B2 cover?
- The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions compris…
- Who is the assignee on this patent?
- Wu Tongfei, Gijsen Henricus Jacobus Maria, Rombouts Frederik Jan Rita, and 11 more
- What technology area does this patent fall under?
- Primary CPC classification C07D403/10. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).