Guanidinobenzoic acid compound
US-9199927-B2 · Dec 1, 2015 · US
Substituted 1, 2, 3, 4-tetrahydroquinolin-7-yl carbamates as acetylcholinesterase inhibitors for treatment of Alzheimer's disease
US8946261B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8946261-B2 |
| Application number | US-201213984998-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 24, 2012 |
| Priority date | Feb 14, 2011 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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The present invention relates to novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, their preparation, and use as therapeutic agents, particularly in the prevention or treatment of neurodegenerative or Alzheimer's disease, or senile dementia, or memory disturbances, and more particularly to the prevention, treatment and amelioration of Alzheimer's disease with the novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, which act as inhibitors of central cholinesterase enzymes, particularly acetylcholinesterase (AChE) following the indirect cholinomimetic pathway. The present invention particularly relates to compounds of formula A: Formula A wherein R 1 =alkyl, aryl, substituted aryl; R 2 =H, methyl; R 3 =H, alkyl, alkenyl, alkynyl, aralkyl, substituted aralkyl, aryl, heteroaryl.
First claim
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We claim: 1. A compound of general formula A wherein: R 1 and R 2 , which may be identical or different, are selected from the group consisting of hydrogen, alkyl (C1-C2), mono- or di-substituted aryl; R 3 is selected from the group, consisting of hydrogen, saturated or unsaturated alkyl (C1-C3), aryl, aralkyl, and alkynyl. 2. The compound as cl…
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- C07D215/20Primary
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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Frequently asked questions
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- What does patent US8946261B2 cover?
- The present invention relates to novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, their preparation, and use as therapeutic agents, particularly in the prevention or treatment of neurodegenerative or Alzheimer's disease, or senile dementia, or memory disturbances, and more particularly to the prevention, treatment and amelioration of Alzheimer's disease with the novel substituted 1…
- Who is the assignee on this patent?
- Roy Kuldeep Kumar, Tota Santoshkumar, Nath Chandishwar, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07D215/20. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).