Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof

Patent metadata

Field	Value
Publication number	US-8946239-B2
Application number	US-17057108-A
Country	US
Kind code	B2
Filing date	Jul 10, 2008
Priority date	Jul 10, 2008
Publication date	Feb 3, 2015
Grant date	Feb 3, 2015

Abstract

The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic compounds of formula III,

and 5,6-saturated and unsaturated

and pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.

First claim

What is claimed is:

1. A compound of Formula III:

and 5,6-saturated and unsaturated
with respect to the five membered ring;
R 1 is CH 3 when R 2 is a methoxyphenyl group, or wherein R 1 is methoxyphenyl group when R 2 is CH 3 ;
R 3 is CH 3 ;
R 5 is CH 3 ;
R 6 is a hydrogen (H);
X is an oxygen (O); and…

Assignees

• Gangjee Aleem
• Univ Holy Ghost Duquesne

Inventors

• Gangjee Aleem

Classifications

• A61P35/04

  Human Necessities · mapped topic

• A61P35/00

  Human Necessities · mapped topic

• C07D491/048 Primary

  Chemistry & Metallurgy · mapped topic

• A61K31/517

  Human Necessities · mapped topic

• C07D239/70

  Chemistry & Metallurgy · mapped topic