Pyridazinedione-based heterobicyclic covalent linkers and methods and applications thereof
US-2024425465-A1 · Dec 26, 2024 · US
Pyrazolo[1,5-A]pyrimidines as mark inhibitors
US8946237B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8946237-B2 |
| Application number | US-201113521382-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 11, 2011 |
| Priority date | Jan 14, 2010 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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The invention encompasses pyrazolo[1,5-a]pyrimidine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.
First claim
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What is claimed is: 1. A compound of formula I: or a pharmaceutically acceptable salt or hydrate thereof; wherein: X 1 is selected from the group consisting of: H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkoxy, —C(O)—OC 1-4 alkyl, C 3-6 cycloalkoxy, CN and N(R 3 ) 2 , wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycl…
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- C07D487/04Primary
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US8946237B2 cover?
- The invention encompasses pyrazolo[1,5-a]pyrimidine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.
- Who is the assignee on this patent?
- Lim Jongwon, Taoka Brandon M, Lee Sandra, and 6 more
- What technology area does this patent fall under?
- Primary CPC classification C07D487/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).