Topical otic, ophthalmic, and nasal corticosteroid formulations
US-2024000801-A1 · Jan 4, 2024 · US
Methods for inhibiting TGF-β
US8946201B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8946201-B2 |
| Application number | US-19945908-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 27, 2008 |
| Priority date | Aug 27, 2007 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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The present invention provides methods for inhibiting or blocking TGF-β activity in cells and/or tissues expressing TGF-β comprising, contacting cells and/or tissues expressing TGF-β with an amount of cholesterol or cholesterol derivative effective to inhibit the activity of TGF-β. The present invention further provides a method for treating a condition associated with overactivity of TGF-β or negative regulation in normal physiology by TGF-β in a subject in need of treatment, comprising contacting cells and/or tissue overexpressing TGF-β in the subject with an amount of cholesterol or cholesterol derivative effective to inhibit activity of TGF-β thereby treating the condition. In a preferred embodiment, the cholesterol derivative is oxidized 7-DHC.
First claim
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What is claimed is: 1. A method for treating dermal wounds in a subject in need of treatment, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a TGF β inhibitor, the TGF β inhibitor consisting of a cholesterol derivative having the Formula II: 2. The method of claim 1 wherein the administering…
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Frequently asked questions
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- What does patent US8946201B2 cover?
- The present invention provides methods for inhibiting or blocking TGF-β activity in cells and/or tissues expressing TGF-β comprising, contacting cells and/or tissues expressing TGF-β with an amount of cholesterol or cholesterol derivative effective to inhibit the activity of TGF-β. The present invention further provides a method for treating a condition associated with overactivity of TGF-β or …
- Who is the assignee on this patent?
- Huang Shuan Shian, Huang Jung San, Univ Saint Louis, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/56. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).