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Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8
US8946181B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8946181-B2 |
| Application number | US-201113519529-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 4, 2011 |
| Priority date | Jan 4, 2010 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Interferon Regulatory Factor 8 (IRF8), in particular, by targeting natural antisense polynucleotides of Interferon Regulatory Factor 8 (IRF8). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IRF8.
First claim
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What is claimed is: 1. A method of upregulating a function of and/or the expression of a Interferon Regulatory Factor 8 (IRF8) polynucleotide in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one modified antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide is specific for and targets a natural antisense polynucleotide of the IRF8 gene and has identity to a reverse complement of…
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- What does patent US8946181B2 cover?
- The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Interferon Regulatory Factor 8 (IRF8), in particular, by targeting natural antisense polynucleotides of Interferon Regulatory Factor 8 (IRF8). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associate…
- Who is the assignee on this patent?
- Collard Joseph, Sherman Olga Khorkova, Curna Inc
- What technology area does this patent fall under?
- Primary CPC classification C12N15/113. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).