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Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US8946151B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8946151-B2 |
| Application number | US-96398604-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 13, 2004 |
| Priority date | Feb 24, 2003 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal multiport brain catheters connected to one or more implantable pumps wherein the flow rate is pulsed.
First claim
Opening claim text (preview).
We claim: 1. A method of producing a sustained increase in dopamine uptake within one or both putamen in a human suffering from Parkinson's disease that comprises locally administering to one or both putamen of a human in need thereof via convection-enhanced infusion using at least one catheter implanted for localized and targeted delivery into the putamen a pharmaceutical composition comprising a pharmaceutically effective amount of a glial cell-line derived neurotrophic factor (G…
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- A61K38/185Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US8946151B2 cover?
- A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one o…
- Who is the assignee on this patent?
- Gill Steven S, Gash Don M, Gerhardt Greg A, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification A61K38/185. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).