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Methods for identifying and isolating cells expressing a polypeptide
US8945878B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945878-B2 |
| Application number | US-201314020030-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 6, 2013 |
| Priority date | Feb 12, 2010 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate cells producing a protein with specific biological functions. In particular, the methods may be used for identifying, selecting, and isolating cells producing antigen-specific monoclonal antibodies.
First claim
Opening claim text (preview).
What is claimed: 1. A method of producing a cell library expressing heterodimeric molecules on the cell surface, comprising: (a) fusing a first population of cells that express a first polypeptide with a second population of cells that comprise a plurality of polynucleotides that encode for a plurality of second polypeptides; wherein the first polypeptide comprises (i) an extracellular portion comprising an immunoglobulin heavy chain constant region comprising CH2 and CH3 domains;…
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Classifications
- C07K14/70514Primary
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
- C12N15/1037Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8945878B2 cover?
- The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate cells producing a protein with specific biological functions. In particular, the methods may be used for identifying, selecting, and isolating cells producing antigen-specific monoclonal antibodies.
- Who is the assignee on this patent?
- Oncomed Pharm Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K14/70514. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).