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Methods and compositions for modification of a HLA locus
US8945868B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945868-B2 |
| Application number | US-201113188417-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 21, 2011 |
| Priority date | Jul 21, 2010 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
First claim
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What is claimed is: 1. A protein comprising an engineered zinc finger DNA-binding domain, wherein the engineered zinc finger DNA-binding domain comprises four, five or six zinc finger DNA recognition regions designated and ordered F1 to F4, F1 to F5 or F1 to F6 from N-terminus to C-terminus and further wherein the engineered zinc finger DNA-binding domain comprises the zinc finger DNA recognition regions selected from the group consisting of: (i) F1: QSSHLTR (SEQ ID NO:1); F2: RS…
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Frequently asked questions
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- What does patent US8945868B2 cover?
- Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
- Who is the assignee on this patent?
- Collingwood Trevor, Cooper Laurence J N, Gregory Philip D, and 7 more
- What technology area does this patent fall under?
- Primary CPC classification C07K14/70539. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).