Method for the determination of botulinum neurotoxin biological activity
US-9212355-B2 · Dec 15, 2015 · US
Methods and kits for ascertaining biosafety of an agent
US8945847B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945847-B2 |
| Application number | US-201113114102-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 24, 2011 |
| Priority date | May 24, 2010 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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A method of ascertaining the bio-safety of an agent is disclosed. The method comprises: (a) contacting the agent with differentiating human pluripotent stem cells; (b) analyzing a level of gene expression of a plurality of genes in the differentiating human pluripotent stem cells, wherein the agent is qualified as being safe if at least one of the following qualification parameters are fulfilled: (i) the agent causes a difference in the level of gene expression below a predetermined number of genes as compared to control differentiating human pluripotent stem cells that have not been contacted with the agent; (ii) the agent causes a difference in gene expression below a predetermined number of tissue-specific genes of a tissue as compared to control differentiating human pluripotent stem cells that have not been contacted with the agent; or (iii) the agent causes a difference in gene expression below a predetermined number of genes involved in fetal development as compared to control differentiating human pluripotent stem cells that have not been contacted with the agent.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of ascertaining the bio-safety of an agent, the method comprising: (a) generating embryoid bodies from human pluripotent stem cells: (b) contacting the agent with said embryoid bodies concomitant with said generating or following said generating; (c) analyzing a level of gene expression of more than 4000 random, non-biased genes in said embryoid bodies; and (d) when said agent is qualified as being safe, testing said agent on an animal model t…
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Chemistry & Metallurgy · mapped topic
- G01N33/5014Primary
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Physics · mapped topic
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Frequently asked questions
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- What does patent US8945847B2 cover?
- A method of ascertaining the bio-safety of an agent is disclosed. The method comprises: (a) contacting the agent with differentiating human pluripotent stem cells; (b) analyzing a level of gene expression of a plurality of genes in the differentiating human pluripotent stem cells, wherein the agent is qualified as being safe if at least one of the following qualification parameters a…
- Who is the assignee on this patent?
- Benvenisty Nissim, Mayshar Yoav, Yanuka Ofra, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5014. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).