Assay and other reactions involving droplets
US-2015353999-A1 · Dec 10, 2015 · US
Multiplexed analyses of test samples
US8945830B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945830-B2 |
| Application number | US-85993010-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 20, 2010 |
| Priority date | Dec 15, 1997 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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- Title
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Abstract
Official abstract text for this publication.
The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).
First claim
Opening claim text (preview).
What is claimed is: 1. A method for detecting a target molecule that may be present in a test sample, the method comprising: (a) contacting a test sample with an aptamer having a specific affinity for a target molecule, wherein an aptamer affinity complex is formed by the interaction of an aptamer with its target molecule, if said target molecule is present in said test sample, wherein said aptamer binds to said target molecule through non-Watson Crick interactions, and wherein th…
Assignees
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Classifications
- C12Q1/6834Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
- C12Q1/6832Primary
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8945830B2 cover?
- The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If t…
- Who is the assignee on this patent?
- Heil James R, Schneider Daniel J, Nieuwlandt Daniel T, and 6 more
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/6834. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).