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Synthetic lipid biology for combinatorial engineering of endotoxin
US8945587B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945587-B2 |
| Application number | US-201313780805-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 28, 2013 |
| Priority date | Feb 28, 2012 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure relates to genetic engineering of Gram-negative bacteria expressing different species of lipid A on their surface. In one embodiment, the present disclosure provides for an engineered strain of E. coli according to Table 1. In another embodiment, the present disclosure provides for a lipopolysaccharide purified from an engineered strain of E. coli according to Table 1.
First claim
Opening claim text (preview).
What is claimed is: 1. An isolated engineered strain of E. coli comprising deletions of lpxT, eptA and pagP genes, said E. coli comprising immunologically active lipid A on its surface. 2. The isolated engineered strain of claim 1 further comprising deletions of the Kan R cassette and lpxM gene. 3. The isolated engineered strain of claim 1 further comprising at least one expression vector that comprises at least one gene encoding a l…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
- C12N15/70Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8945587B2 cover?
- The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure relates to genetic engineering of Gram-negative bacteria expressing different species of lipid A on their surface. In one embodiment, the present disclosure provides for an engineered strain of E. coli according to Table 1. In another embodiment, the present disclosure provid…
- Who is the assignee on this patent?
- Univ Texas, Univ Texas
- What technology area does this patent fall under?
- Primary CPC classification C12N15/70. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).