Methods and compositions for cancer treatment
US-2024424094-A1 · Dec 26, 2024 · US
US8945557B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945557-B2 |
| Application number | US-201213661717-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 26, 2012 |
| Priority date | Oct 21, 2004 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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The present invention relates to use of an antagonist of BIR1 (B cell immunoglobulin receptor 1) related to the present invention, a method for screening the antagonist, in addition to subtype polypeptides of BIR1, the polynucleotide encoding them and antibodies for the polypeptides. BIR1 functions as an immunosuppressive receptor, and the antagonist of BIR1 has immunopotentive activity, which is able to use for preventing and/or treating a cancer, an immunodeficiency disease or an infectious disease.
Opening claim text (preview).
The invention claimed is: 1. A method for potentiating an immune response comprising: administering to a subject in need thereof an effective amount of an antagonist of a protein, said protein having the amino acid sequence of any one of SEQ ID NOs: 1 to 6, wherein the antagonist is an isolated monoclonal antibody or fragment thereof that specifically binds to a protein having the amino acid sequence of any one of SEQ ID NOs: 1 to 6. 2. The method of claim…
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