Compositions and methods that inhibit il-23 signaling
US-2024425579-A1 · Dec 26, 2024 · US
US8945545B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945545-B2 |
| Application number | US-201213415337-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 8, 2012 |
| Priority date | Mar 18, 2008 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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The invention provides a method of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
Opening claim text (preview).
The invention claimed is: 1. A method of treating psoriasis in a subject comprising administering to the subject an antibody, or antigen-binding portion thereof, which is capable of binding to an epitope of the p40 subunit of IL-12 and/or IL-23, for a first extended period of at least about 4 weeks, wherein the subject achieves at least a Psoriasis Area and Severity Index (PASI) 75 response by at least about week 12 following initial administration of the antibody, or antigen-bind…
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