Robot system
US-2024216091-A1 · Jul 4, 2024 · US
System, method and device for tissue-based diagnosis
US8945482B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8945482-B2 |
| Application number | US-201013126105-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 12, 2010 |
| Priority date | Feb 13, 2009 |
| Publication date | Feb 3, 2015 |
| Grant date | Feb 3, 2015 |
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Abstract
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The current invention provides devices, methods and systems involving application of energy and/or a liquefaction promoting medium to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, tissue decontamination as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types of biomolecules, drugs, and microbes). In addition, the current invention provides specific compositions of the said liquefaction promoting medium so as to facilitate liquefaction, preserve liquefied tissue constituents, and enable delivery of molecules into tissues. Determination of tissue composition in the liquefied tissue sample can be used in a variety of applications, including diagnosis or prognosis of local as well as systemic diseases, evaluating bioavailability of therapeutics in different tissues following drug administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and various other applications. The methods, devices and systems are used to deliver one or more drugs through or into the site of the tissue to be liquefied.
First claim
Opening claim text (preview).
The invention claimed is: 1. A device for at least partly liquefying a tissue, comprising: a reservoir; an abrasive material operatively coupled to the reservoir, the reservoir being configured to transmit mechanical energy through the abrasive material to the tissue in the form of stirring, abrasion, pressure, or shear force; and a liquefaction promoting medium, the liquefaction promoting medium comprising a non-ionic surfactant and a zwitterionic surfactant, the zwitterionic…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Physics · mapped topic
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Frequently asked questions
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- What does patent US8945482B2 cover?
- The current invention provides devices, methods and systems involving application of energy and/or a liquefaction promoting medium to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, tissue decontamination as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., s…
- Who is the assignee on this patent?
- Mitragotri Samir, Paliwal Sumit, Ogura Makoto, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61B10/02. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).