Spiroquinone derivative compound, production method thereof, and pharamaceutical composition for preventing or treating neurological disorders which contains same as active ingredient
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Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient
US8940936B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940936-B2 |
| Application number | US-201113880642-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 17, 2011 |
| Priority date | Oct 20, 2010 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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- Title
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Abstract
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The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound represented by the following formula 1 or a pharmaceutically acceptable salt thereof: (In the formula 1, R 1 is C 1-10 straight or branched alkyl, or C 8-12 bicyclic ring, R 2 is —H, COOR 5 , COOR 5 R 6 , —SO 2 NH 2 , —SO 2 —(C 1-4 straight or branched alkyl), or —CONHR 7 , R 3 is —H, —OH, or —COO—(C 1-4 str…
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Classifications
Human Necessities · mapped topic
- C07C235/28Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8940936B2 cover?
- The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell gro…
- Who is the assignee on this patent?
- Lee Kyeong, Won Mi Sun, Kim Hwan Mook, and 11 more
- What technology area does this patent fall under?
- Primary CPC classification C07C235/28. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).