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US-12171741-B2 · Dec 24, 2024 · US
Squarylated lactones inhibitors for bacterial biofilm formation
US8940911B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940911-B2 |
| Application number | US-201313957038-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 1, 2013 |
| Priority date | Aug 1, 2012 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
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A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (˜200 μM), these small molecules inhibit biofilm formation of E. coli . Moreover, these compounds are not toxic up to 300 μM and do not significantly attenuate E. coli growth. The SHLs have potential to disperse established biofilm and demonstrate an enhanced reduction (˜50%) of the maximum biofilm thickness by use of SHLs during biofilm growth.
First claim
Opening claim text (preview).
What is claimed is: 1. A squarylated homoserine lactone, comprising the structure: wherein R is a group selected from the group consisting of methyl, ethyl, n-butyl, n-hexyl, phenyl, tolyl, and thienyl. 2. The squarylated homoserine lactone of claim 1 , wherein said squarylated homoserine lactone is characterized by an ability to modulate quorum sensi…
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Chemistry & Metallurgy · mapped topic
- C07D409/12Primary
Chemistry & Metallurgy · mapped topic
- C07D307/20Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8940911B2 cover?
- A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (˜200 μM), these small molecules inhibit biofilm formation of E. coli . Moreover, these compounds are not toxic up to 300 μM and do not significantly attenuate E. coli growth. The SHLs have potential to dispe…
- Who is the assignee on this patent?
- Luk Yan-Yeung, Narasimhan Sri Kamesh, Falcone Eric, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07D409/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).