Compositions and methods of inhibiting gene expression in a lung
US-2015368648-A1 · Dec 24, 2015 · US
RNAi-mediated inhibition of HIF1A for treatment of ocular angiogenesis
US8940887B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940887-B2 |
| Application number | US-201313904431-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 29, 2013 |
| Priority date | Dec 29, 2005 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
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RNA interference is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions.
First claim
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What is claimed is: 1. A pharmaceutical composition comprising: an interfering RNA that contains one or more chemically modified nucleotides, one or more deoxyribonucleotides, and/or one or more non-phosphodiester linkages, and a pharmaceutically acceptable carrier, wherein the interfering RNA has a sense strand and an antisense strand, wherein each strand is 19-49 nucleotides in length, and wherein the sense strand comprises the RNA sequence corresponding to SEQ ID NO: 11, wherein…
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Frequently asked questions
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- What does patent US8940887B2 cover?
- RNA interference is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions.
- Who is the assignee on this patent?
- Alcon Res Ltd
- What technology area does this patent fall under?
- Primary CPC classification C12N15/1136. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).