St2 antigen binding proteins
US-2024368292-A1 · Nov 7, 2024 · US
US8940877B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940877-B2 |
| Application number | US-201213653332-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 16, 2012 |
| Priority date | May 26, 2010 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
Opening claim text (preview).
What is claimed is: 1. A method for preparing an enriched IgG composition from plasma, the method comprising the steps of: (a) precipitating a cryo-poor plasma fraction, in a first precipitation step, with from about 6% to about 10% alcohol at a pH of from about 7.0 to about 7.5 to obtain a first precipitate and a first supernatant; (b) precipitating IgG from the first supernatant, in a second precipitation step, with from about 23% to about 27% alcohol at a pH of from about 6.7…
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