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US-2019284224-A1 · Sep 19, 2019 · US
10′-fluorinated Vinca alkaloids provide enhanced biological activity against MDR cancer cells
US8940754B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940754-B2 |
| Application number | US-201113580340-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 9, 2011 |
| Priority date | Feb 22, 2010 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
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A 10′-fluoro-vinca alkaloid compound or its pharmaceutically acceptable salt is disclosed, as are methods of its preparation and use. A disclosed 10′-fluoro-vinca alkaloid compound has better cytotoxic potency against leukemia and cancer cell lines, and is about 8-times more cytotoxic to a multiple drug resistant cancer cell line than is a parental 10′-unsubstituted vinca alkaloid.
First claim
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What is claimed: 1. A 10′-fluoro-vinca alkaloid compound or its pharmaceutically acceptable salt that corresponds in structure to a compound shown in Tables A or B below: TABLE A…
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Human Necessities · mapped topic
Human Necessities · mapped topic
- C07D519/04Primary
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US8940754B2 cover?
- A 10′-fluoro-vinca alkaloid compound or its pharmaceutically acceptable salt is disclosed, as are methods of its preparation and use. A disclosed 10′-fluoro-vinca alkaloid compound has better cytotoxic potency against leukemia and cancer cell lines, and is about 8-times more cytotoxic to a multiple drug resistant cancer cell line than is a parental 10′-unsubstituted vinca alkaloid.
- Who is the assignee on this patent?
- Boger Dale L, Scripps Research Inst
- What technology area does this patent fall under?
- Primary CPC classification C07D519/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).