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US-12172037-B2 · Dec 24, 2024 · US
Inhibitors of TLR signaling by targeting TIR domain interfaces
US8940703B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940703-B2 |
| Application number | US-201313761277-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 7, 2013 |
| Priority date | Feb 7, 2012 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
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TIR-domain decoy peptides and TIR domain peptides are disclosed, as well as methods of using the peptides in the regulation of toll-like receptor (TLR) activation and signaling.
First claim
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What is claimed is: 1. A method of inhibiting TIR:TIR interaction between two TIR (Toll/IL-1 receptor) domain-bearing proteins, comprising contacting a cell expressing TIR domain-bearing proteins with one or more TIR-derived decoy peptides, wherein the TIR-derived decoy peptides are selected from the group consisting of: TRAP (Toll/interleukin-1 receptor domain-containing adapter protein) based, TIR-derived decoy peptides TR3 (RQIKIWFQNRRMKWKKEGSQASLRCF; SEQ ID NO:1), TR5 (RQIKI…
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- C07K14/705Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07K7/08Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8940703B2 cover?
- TIR-domain decoy peptides and TIR domain peptides are disclosed, as well as methods of using the peptides in the regulation of toll-like receptor (TLR) activation and signaling.
- Who is the assignee on this patent?
- Univ Maryland
- What technology area does this patent fall under?
- Primary CPC classification C07K14/705. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).