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Host cell protein knock-out cells for production of therapeutic proteins
US8940504B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940504-B2 |
| Application number | US-201213418844-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 13, 2012 |
| Priority date | Jul 13, 2005 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
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The present invention relates to methods and means for making Vitamin K-dependent protein compositions which are devoid or substantially devoid of protein contaminants. In particular, methods and means useful for the reduction or elimination of protein contaminants also being Vitamin K-dependent proteins are described.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for producing a composition comprising a Vitamin K-dependent protein of interest having a substantially lower amount of protein contaminant Protein S expressed endogenously by a Chinese Ovary Hamster (CHO) host cell in the absence of modification, said method comprising the steps of: a) producing said host cell expressing a Vitamin K-dependent protein of interest comprising the following steps in any order: 1) transfecting a cell with a polyn…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C12N9/647Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8940504B2 cover?
- The present invention relates to methods and means for making Vitamin K-dependent protein compositions which are devoid or substantially devoid of protein contaminants. In particular, methods and means useful for the reduction or elimination of protein contaminants also being Vitamin K-dependent proteins are described.
- Who is the assignee on this patent?
- Steenstrup Thomas Dock, Norby Peder Lisby, Novo Nordisk Healthcare Ag
- What technology area does this patent fall under?
- Primary CPC classification C12N9/647. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).