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US-2015376678-A1 · Dec 31, 2015 · US
Method of detecting botulinum neurotoxin and antibodies that neutralize botulinum neurotoxin action
US8940477B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940477-B2 |
| Application number | US-29141108-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 10, 2008 |
| Priority date | Nov 8, 2007 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
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A highly sensitive method of analyzing a sample for the presence or activity of botulinum neurotoxin (BoNT) or antibodies specific for botulinum neurotoxin is disclosed. In one embodiment, the method comprises the steps of preparing primary non-human mammalian or avian spinal cord cells, and exposing the cells to a test sample, in parallel with a control sample, and examining the extent of cleavage of the intracellular neuronal target protein in both the test and control sample.
First claim
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We claim: 1. A method of analyzing a sample for the presence or activity of botulinum neurotoxin (BoNT) or antibodies specific for botulinum neurotoxin, comprising the following steps: a) preparing primary non-human mammalian or avian spinal cord cells in media that contain no serum or growth inhibitors, and b) exposing the cells to a test sample, in parallel with a control sample, and examining the extent of cleavage of the intracellular neuronal target protein in both the test…
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- C12Q1/37Primary
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
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- What does patent US8940477B2 cover?
- A highly sensitive method of analyzing a sample for the presence or activity of botulinum neurotoxin (BoNT) or antibodies specific for botulinum neurotoxin is disclosed. In one embodiment, the method comprises the steps of preparing primary non-human mammalian or avian spinal cord cells, and exposing the cells to a test sample, in parallel with a control sample, and examining the extent of clea…
- Who is the assignee on this patent?
- Johnson Eric A, Pellett Sabine, Tepp William H, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/37. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).