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High-molecular weight conjugate of podophyllotoxins
US8940332B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940332-B2 |
| Application number | US-22696207-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 16, 2007 |
| Priority date | May 18, 2006 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
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A novel podophyllotoxin derivative, which is capable of releasing a drug without depending on biological enzymes and can be expected to have an effective therapeutic effect and is soluble in water has been demanded. A polymer having a polyethyleneglycol structural unit and two or more succinic monoamide structural units, particularly a polymer conjugate of a podophyllotoxin in which a carboxylic acid group of polyethyleneglycol/polyaspartic acid copolymer and a hydroxyl group of podophyllotoxin and linked via an ester bond is provided.
First claim
Opening claim text (preview).
The invention claimed is: 1. A high-molecular weight conjugate of podophyllotoxins, represented by formula (I): wherein R1 represents a hydrogen atom or a (C1-C6) alkyl group; R2 represents a linking group; R3 represents a hydrogen atom or a (C1-C6) acyl group; R4 represents the residue of a hydroxyl group of the podophyllotoxins; R5 represents a group selected from the group c…
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Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8940332B2 cover?
- A novel podophyllotoxin derivative, which is capable of releasing a drug without depending on biological enzymes and can be expected to have an effective therapeutic effect and is soluble in water has been demanded. A polymer having a polyethyleneglycol structural unit and two or more succinic monoamide structural units, particularly a polymer conjugate of a podophyllotoxin in which a carboxyli…
- Who is the assignee on this patent?
- Kitagawa Masayuki, Ishikawa Keizou, Yamamoto Keiichirou, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/7048. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).