Methods and compositions for cancer treatment
US-2024424094-A1 · Dec 26, 2024 · US
Predicting response to a HER inhibitor
US8940302B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940302-B2 |
| Application number | US-201213648085-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 9, 2012 |
| Priority date | Mar 2, 2007 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
Official abstract text for this publication.
The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. It also describes the use of high HER2:HER3 ratio as a selection criterion for treating cancer patients, such as ovarian cancer patients, with a HER inhibitor, such as pertuzumab. In addition, the application describes the use of high HER3 as a selection criterion for treating cancer patients with a chemotherapeutic agent, for instance gemcitabine.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for treating a patient with a type of cancer which is able to respond to a HER2 dimerization inhibitor antibody, comprising administering to the patient a therapeutically effective amount the HER2 antibody, wherein the patient's cancer has been determined to express HER3 at a level less than the median level for HER3 expression in the cancer type, and wherein the HER2 antibody comprises the variable light and variable heavy amino acid sequences in SE…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Physics · mapped topic
Physics · mapped topic
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Frequently asked questions
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- What does patent US8940302B2 cover?
- The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. It also describes the use of high HER2:HER3 ratio as a selection criterion for treating cancer patients, such as ovarian cancer patients, with a HER inhibitor, such as pertuzumab. In addition, the application describes the use of high HER3 as…
- Who is the assignee on this patent?
- Genentech Inc, Hoffmann La Roche
- What technology area does this patent fall under?
- Primary CPC classification A61K39/39558. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).