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Urate transporter, as well as method and kit for evaluating urate transport-related disease factor and inflammation-related disease factor, and test sample and drug
US8940286B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940286-B2 |
| Application number | US-201013379346-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 22, 2010 |
| Priority date | Jun 22, 2009 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
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A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.
First claim
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The invention claimed is: 1. A high capacity urate transporter formulation, comprising: a polypeptide having (i) an amino acid sequence consisting of SEQ ID NO:62; and, (ii) a cell membrane permeating peptide; wherein, the polypeptide is a cross-linked polypeptide having the cell membrane permeating peptide linked to SEQ ID NO:62 through a cross-linking agent. 2. The formulation of claim 1 , wherein the amino acid sequence consisting of SEQ ID NO:62 is syn…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US8940286B2 cover?
- A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V,…
- Who is the assignee on this patent?
- Matsuo Hirotaka, Shinomiya Nariyoshi, Nakamura Takahiro, and 7 more
- What technology area does this patent fall under?
- Primary CPC classification C07K14/705. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).