Ph measuring cell
US-2024011933-A1 · Jan 11, 2024 · US
Functionalized nanopipette biosensor
US8940142B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8940142-B2 |
| Application number | US-43505609-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 4, 2009 |
| Priority date | May 5, 2008 |
| Publication date | Jan 27, 2015 |
| Grant date | Jan 27, 2015 |
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Abstract
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Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction withy peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of Il-10 at a concentration of 4ng/nl is also disclosed, as is detection of VEGF.
First claim
Opening claim text (preview).
What is claimed is: 1. A device for specific detection of one or more analytes in a sample containing electrolyte, comprising: (a) a quartz or glass capillary nanopipette having a tip with a nanoscale opening between an interior of the nanopipette and an external area for contacting the sample, said nanopipette having a hollow structure defining an internal volume communicating with the sample and said nanoscale opening of between 10 and 100 nm in diameter and constructed so that…
Assignees
Inventors
Classifications
- G01N27/4035Primary
Physics · mapped topic
- G01N33/48707Primary
Physics · mapped topic
- G01N27/42Primary
Physics · mapped topic
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Frequently asked questions
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- What does patent US8940142B2 cover?
- Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific rea…
- Who is the assignee on this patent?
- Karhanek Miloslav, Webb Chris D, Umehara Senkei, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification G01N27/4035. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jan 27 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).