Triazole compounds that modulate HSP90 activity

Patent metadata

Field	Value
Publication number	US-8937094-B2
Application number	US-201313941081-A
Country	US
Kind code	B2
Filing date	Jul 12, 2013
Priority date	Aug 8, 2008
Publication date	Jan 20, 2015
Grant date	Jan 20, 2015

Abstract

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.

First claim

What is claimed is:

1. A compound selected from the group consisting of:
5-(4-ethoxy-2-hydroxyphenyl)-4-(4-(morpholinomethyl)phenyl)-4H-1,2,4-triazole-3-carboxamide;
5-(2-hydroxy-4-methoxyphenyl)-4-(4-(morpholinomethyl)phenyl)-4H-1,2,4-triazole-3-carboxamide;
5-(2-hydroxy-4-propoxyphenyl)-4-(4-(morpholinomethyl)phenyl)-4H-1,2,4-triazole-3-carboxamide;
5-(2-hydroxy-4-isopropoxyphenyl)-4-(4-(morpholinomethyl)phenyl)-4H-1,2,4-triazole-3-carboxamide;
5-(2,4-dimethoxyphenyl)-4-…

Assignees

• Synta Pharmaceuticals Corp

Inventors

• Burlison Joseph
• Zhang Shijie
• Ying Weiwen
• Chimmanamada Dinesh U
• Song Minghu
• Chae Junghyun
• Schweizer Stefan M

Classifications

• A61P37/00

  Human Necessities · mapped topic

• C07D405/06

  Chemistry & Metallurgy · mapped topic

• C07D249/08

  Chemistry & Metallurgy · mapped topic

• A61K31/496

  Human Necessities · mapped topic

• A61K31/5377

  Human Necessities · mapped topic