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Method for enhancing folding and transport of misfolded glucocerebrosidase
US8937059B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8937059-B2 |
| Application number | US-201414255479-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 17, 2014 |
| Priority date | Sep 17, 2007 |
| Publication date | Jan 20, 2015 |
| Grant date | Jan 20, 2015 |
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Abstract
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Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
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What is claimed: 1. A method of enhancing transport of misfolded GCase to a lysosome in a patient suffering from Parkinson's Disease, consisting of administering to the patient a pharmaceutically acceptable amount of ambroxol, ambroxol hydrochloride, or bromhexine or a pharmaceutically acceptable salt thereof, wherein said ambroxol, ambroxol hydrochloride or bromhexine or a pharmaceutically acceptable salt thereof enhances transport of the misfolded GCase to the lysosome.…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US8937059B2 cover?
- Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
- Who is the assignee on this patent?
- Hospital For Sick Children, Univ Mcmaster
- What technology area does this patent fall under?
- Primary CPC classification A61K31/137. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 20 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).