Insecticidal proteins and methods for their use
US-12168774-B2 · Dec 17, 2024 · US
Pseudomonas exotoxin a with reduced immunogenicity
US8936792B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8936792-B2 |
| Application number | US-201013395422-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 10, 2010 |
| Priority date | Sep 11, 2009 |
| Publication date | Jan 20, 2015 |
| Grant date | Jan 20, 2015 |
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Abstract
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The present invention provides improved Pseudomonas Exotoxin A (PE) molecules with high cytotoxicity and reduced immunogenicity, compositions containing the improved (PE), and methods of use.
First claim
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What is claimed is: 1. An isolated Pseudomonas exotoxin A (“PE”), wherein said PE has residues 1-273 and 285-394 removed and substitutions of alanine, glycine or serine in place of amino acid residues D406, R432, R467, R490, R513, E548, K590 and Q592 corresponding to an amino acid residue of SEQ ID NO:1. 2. A PE of claim 1 , wherein said PE further has a substitution of alanine, glycine or serine of at least one amino acid residue corresponding to an amino acid…
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Frequently asked questions
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- What does patent US8936792B2 cover?
- The present invention provides improved Pseudomonas Exotoxin A (PE) molecules with high cytotoxicity and reduced immunogenicity, compositions containing the improved (PE), and methods of use.
- Who is the assignee on this patent?
- Pastan Ira H, Beers Richard, Onda Masanori, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07K14/21. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 20 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).