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Method of hepatocellular carcinoma classification and prognosis

US8935102B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8935102-B2
Application numberUS-9560406-A
CountryUS
Kind codeB2
Filing dateNov 30, 2006
Priority dateNov 30, 2005
Publication dateJan 13, 2015
Grant dateJan 13, 2015

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  1. Title

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  2. Abstract

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  5. First independent claim

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Abstract

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Methodology for the in vitro classification and/or prognosis of hepatocellular carcinoma (HCC) from a HCC sample is based on the determination of the expression profile of particular gene combinations. For example, in one embodiment, a method comprises measuring the expression level in an HCC sample of at least 8 genes selected from the group consisting of: RAB1A, REG3A, NRAS, RAMP3, MERTK, PIR, EPHA1, LAMA3, G0S2, HN1, PAK2, AFP, CYP2C9, CDH2, HAMP, SAE1, ADH6, DCN, FLJ10159, ALDH1L1, IGF1, LECT2, SLC38A1, SPARCL1, CTNNA2, GLUL, LEF1, MATN2, MME, PFN2, SPINT2, TBX3, and FGFR2; b) calculating 6 subgroup distances from the expression profile; and c) classifying the HCC tumor in the subgroup for which the subgroup distance is the lowest, wherein the 6 subgroups G1, G2, G3, G4, G5, and G6 are defined by the presence (+) or absence (−) of their clinical and genetic features.

First claim

Opening claim text (preview).

The invention claimed is: 1. A method for the classification of a hepatocellular carcinoma (HCC) tumor between six subgroups from a liver HCC sample of a human subject suffering from HCC, comprising: a) measuring, in vitro, the nucleic acid expression level of a group of selected genes in said liver HCC sample, wherein the group of selected genes comprises a combination of at least eight genes selected from the group consisting of: RAB1A, REG3A, NRAS, RAMP3, MERTK, PIR, EPHA1, LAM…

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What does patent US8935102B2 cover?
Methodology for the in vitro classification and/or prognosis of hepatocellular carcinoma (HCC) from a HCC sample is based on the determination of the expression profile of particular gene combinations. For example, in one embodiment, a method comprises measuring the expression level in an HCC sample of at least 8 genes selected from the group consisting of: RAB1A, REG3A, NRAS, RAMP3, MERTK, PIR…
Who is the assignee on this patent?
Zucman-Rossi Jessica, De Reynies Aurélien, Rickman David, and 2 more
What technology area does this patent fall under?
Primary CPC classification C12Q1/6886. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Jan 13 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).