3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof

Patent metadata

Field	Value
Publication number	US-8933248-B2
Application number	US-201313921957-A
Country	US
Kind code	B2
Filing date	Jun 19, 2013
Priority date	Jun 21, 2012
Publication date	Jan 13, 2015
Grant date	Jan 13, 2015

Abstract

The present invention relates to expedient method for synthesis of 3-substituted-3-hydroxy-oxindole derivatives, which are useful as synthetic precursors to valuable pharmaceutical compounds. These are synthesized by reacting nitromethane with the corresponding isatins of formula (I). The reaction process of isatins was carried using water as a solvent at room temperature to form the corresponding 3-hydroxy-3-nitromethylindolin-2-ones of formula (II).

First claim

We claim:

1. A 3-hydroxy-3-nitromethyl indolin-2-one derivative compound of general formula II:

wherein:
R=H or C 7 H 6 —X;
R 1 =H, X 1 at C-7 position, or X 2 at C-5 position;
X=H, Br, or Cl;
X 1 =I or F;
X 2 =H, Cl or Br,
wherein:
when, R=H; R 1 =X 1 at C-7 position;
when, R=C 7 H 6 —X; then R…

Assignees

• Council Scient Ind Res

Inventors

• Rao Mandapati Mohan
• Prathima Parvathaneni Sai

Classifications

• C07D209/38 Primary

  Chemistry & Metallurgy · mapped topic