Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations
US-2015376230-A1 · Dec 31, 2015 · US
Peptide chromatographic purification assisted by combining of solubility parameter and solution conformation energy calculations
US8933196B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8933196-B2 |
| Application number | US-201213472152-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 15, 2012 |
| Priority date | May 20, 2011 |
| Publication date | Jan 13, 2015 |
| Grant date | Jan 13, 2015 |
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Abstract
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A method of purifying a compound from a mixture through a chromatographic column loaded with a column adsorbent. The method comprises: applying the mixture to the chromatographic column; eluting the mixture with an elution solvent composition; and collecting the compound; wherein at least one of the column adsorbent and elution solvent is selected based on one of solubility parameters of the compound, column adsorbent, elution solvent, and conformation energy of the compound.
First claim
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What is claimed is: 1. A method of identifying, quantifying, or purifying a compound from a mixture through a chromatographic column loaded with a column adsorbent comprising: A) selecting at least one of the column adsorbent and eluting solvent composition by performing the following steps: a) identifying a critical pair composed of the compound and an impurity; b) 1. if the differential CD spectra (Δθ) from 200 nm to 250 nm between the critical pair is larger than 5000 cm 2…
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- C07K1/20Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8933196B2 cover?
- A method of purifying a compound from a mixture through a chromatographic column loaded with a column adsorbent. The method comprises: applying the mixture to the chromatographic column; eluting the mixture with an elution solvent composition; and collecting the compound; wherein at least one of the column adsorbent and elution solvent is selected based on one of solubility param…
- Who is the assignee on this patent?
- Chen Wen-Yih, Chang Li-Chiao, Ruaan Ruoh-Chyu, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07K1/20. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 13 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).