Glycopeptide antibiotic derivative

Patent metadata

Field	Value
Publication number	US-8933012-B2
Application number	US-22444307-A
Country	US
Kind code	B2
Filing date	May 25, 2007
Priority date	May 26, 2006
Publication date	Jan 13, 2015
Grant date	Jan 13, 2015

Abstract

The present invention provides a novel glycopeptide antibiotic derivative.
These derivatives are represented by the formula (I)

or a pharmaceutically acceptable salt or solvate thereof,

wherein

R A is

—X 1 —Ar 1 —X 2 —Y—X 3 —Ar 2
wherein
X 1 , X 2 and X 3 are single bond; heteroatom-containing group selected from the group consisting of —N═, ═N—, —NR 1 — (R 1 is hydrogen or lower alkyl), —O—, —S—, —SO— and —SO 2 —, or a linkage thereof; or alkylene or alkenylene optionally substituted and optionally interrupted by one or more of said heteroatom-containing group; Y is —NR 2 CO—, —CONR 2 — (R 2 is hydrogen or lower alkyl), or a group of the formula (II) wherein R 3 is alkylene; Ar 1 and Ar 2 are a carbocycle or a heterocycle which is optionally substituted and may have an unsaturated bond;

R B is

—NHNR X R Y or —NR Z OR W

wherein
R X is hydrogen or lower alkyl; R Y is hydrogen, optionally substituted lower alkyl, C(═NH)NH 2 , CSNH 2 , COCONH 2 , CN, optionally substituted heterocyclic group, and optionally substituted carbamoyl; R Z is hydrogen or lower alkyl; R W is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted heterocyclic group, optionally substituted heterocyclic carbonyl or optionally substituted carbamoyl;

R C is hydrogen or optionally substituted alkyl, wherein said alkyl may be interrupted by a heteroatom-containing group selected from N═, ═N—, —NR 1 — (R 1 is hydrogen or lower alkyl), —O—, —S—, —SO— and —SO 2 —; and

R is optionally substituted alkyl.

First claim

What is claimed is:

1. A compound of the formula:

or a pharmaceutically acceptable salt thereof, wherein R A is
—X 1 —Ar 1 —X 2 —Y—X 3 —Ar 2

wherein
X 1 is C 1 -C 3 alkylene;
X 2 is a single bond;
X 3 is a single bond;
Y is —NR 2 CO— or —CONR 2 -wherein R 2 is hydrogen or lower alkyl; and
Ar 1 is a carbo…

Assignees

• Nishitani Yasuhiro
• Yoshida Osamu
• Iwaki Tsutomu
• Kato Issei
• Shionogi & Co

Inventors

• Nishitani Yasuhiro
• Yoshida Osamu
• Iwaki Tsutomu
• Kato Issei

Classifications

• C07K9/008 Primary

  Chemistry & Metallurgy · mapped topic

• A61K38/00

  Human Necessities · mapped topic

• A61P43/00

  Human Necessities · mapped topic

• A61P31/04

  Human Necessities · mapped topic

• A61K38/04

  Human Necessities · mapped topic