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Process for preparing a particle comprising a biological molecule and a carrier polymer
US8932640B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8932640-B2 |
| Application number | US-27885507-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 8, 2007 |
| Priority date | Feb 9, 2006 |
| Publication date | Jan 13, 2015 |
| Grant date | Jan 13, 2015 |
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Abstract
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A process for preparing a particle comprising a biological molecule typically a DNA plasmid, and a carrier polymer, typically poly-lactic acid (PLA), in which an organic solvent solution of the biological molecule and the carrier polymer in an organic solvent medium, nearly saturated with the biological molecule, is prepared, then this solution is contacted with an antisolvent substance, typically supercritical carbon dioxide to separate a particle comprising the biological molecule and the carrier polymer. High loadings of the biological molecule in the particle can be achieved.
First claim
Opening claim text (preview).
The invention claimed is: 1. A process for preparing a particle comprising DNA and a carrier polymer which comprises a polyhydroxy acid or polymer based on a polyhydroxy acid having a molecular weight in the range ca. 5000 to 150,000, and wherein the carrier polymer incorporates 0.1-1.0 wt % polyvinylpyrrolidone (PVP), comprising the steps of: providing a solution of the DNA and the carrier polymer in an organic solvent medium being a mixture of a first, more polar, organic solven…
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Classifications
Human Necessities · mapped topic
- A61K48/00Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US8932640B2 cover?
- A process for preparing a particle comprising a biological molecule typically a DNA plasmid, and a carrier polymer, typically poly-lactic acid (PLA), in which an organic solvent solution of the biological molecule and the carrier polymer in an organic solvent medium, nearly saturated with the biological molecule, is prepared, then this solution is contacted with an antisolvent substance, typica…
- Who is the assignee on this patent?
- Robertson John, Smith Kenneth Baird, Glaxo Group Ltd
- What technology area does this patent fall under?
- Primary CPC classification A61K48/00. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 13 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).