Hybrid and chimeric polypeptides that regulate activation of complement

Patent metadata

Field	Value
Publication number	US-8932601-B2
Application number	US-201113306631-A
Country	US
Kind code	B2
Filing date	Nov 29, 2011
Priority date	Jan 21, 2004
Publication date	Jan 13, 2015
Grant date	Jan 13, 2015

Abstract

A hybrid complement-regulating protein comprises a first functional unit of a first complement regulatory protein having complement regulating properties, a first spacer sequence of at least about 200 amino acids encoding a polypeptide that does not exhibit complement regulating properties and at least a second functional unit attached to the spacer sequence. The second functional unit may be a polypeptide providing a functional unit of a second complement regulatory protein, a polypeptide derived from an immunoglobulin, or a polypeptide that enhances binding of the protein to an animal cell. The hybrid protein may also contain a second spacer sequence and a third functional unit of a complement regulatory protein, a polypeptide derived from an immunoglobulin, and a polypeptide that enhances binding of the protein to an animal cell. The optional third functional unit may be the same or different from the first or second functional units.

First claim

We claim:

1. A hybrid protein consisting of:
a functional unit of a complement regulatory protein, the functional unit consisting of Complement Control Protein repeats (CCPs) 2, 3 and 4 of human DAF or CCPs 1, 2, 3, and 4 of human DAF, the functional unit having decay accelerating activity against classical pathway and alternative pathway convertase,
a targeting moiety that enhances binding of the hybrid protein to an animal tissue, wherein the targeting moiety is a lipid tail t…

Assignees

• Medof M Edward
• Kuttner-Kondo Lisa
• Univ Case Western Reserve

Inventors

• Medof M Edward
• Kuttner-Kondo Lisa

Classifications

• C07K14/70596 Primary

  Chemistry & Metallurgy · mapped topic

• A61P37/00

  Human Necessities · mapped topic